Abiola F Adenowo1,
Muhibah F Ilori1,
Fatai O Balogun2,
Mutiu I Kazeem2 
For correspondence:- Mutiu Kazeem Email: mikazeem@gmail.com
Received: 25 April 2014 Accepted: 2 October 2014 Published: 24 November 2014
Citation: Adenowo AF, Ilori MF, Balogun FO, Kazeem MI. Protective Effect of Ethanol Leaf Extract of Carica papaya Linn (Caricaceae) in Alloxan-induced Diabetic Rats. Trop J Pharm Res 2014; 13(11):1877-1882 doi: 10.4314/tjpr.v13i11.15
© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the ameliorative effect of ethanolic extract of Carica papaya leaves in alloxan - induced diabetic rats.
Methods: Rats were randomly divided into five groups of eight animals each. Group A (control) comprised normal healthy animals which were orally administered 1.0 ml of distilled water daily for 21 days while groups B – E consisted of alloxan-induced diabetic rats. Group B comprised diabetic untreated rats, and groups C and D received 1.0 ml of 250 mg/kg and 500 mg/kg body weight of the extract, respectively. Group E received 300 mg/kg of metformin.
Results: Administration of the extract to the diabetic rats significantly reduced (p < 0.05) glucose level (123.50 mg/dl), total cholesterol (TC), triglyceride (1.24 mg/dl) and low density lipoprotein cholesterol (LDL-C), while significantly increasing (p < 0.05) high density lipoprotein cholesterol (HDL-C) and total protein level (66.51 g/dl) compared to the diabetic untreated rats. The extract also significantly decreased (p < 0.05) the concentration of serum urea (12.35 mg/dl), creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of the diabetic rats.
Conclusion: The ethanol leaf extract of Carica papaya ameliorates metabolic disorder caused by diabetes in rats.
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